UC San Diego
COGS 137 - Fall 2024
2023-10-03
Coming Soon
Q:
A:
Coming Soon
Source: https://academic.oup.com/clinchem/article/59/3/478/5621997
Evidence suggests recent smoking and/or blood THC concentrations 2–5 ng/mL are associated with substantial driving impairment, particularly in occasional smokers.link
As of 2021…link
Various approaches:
Focus here: Can we identify a biomarker of recent use?
Which compound, in which matrix, and at what cutoff is the best biomarker of recent use?
Source: Hoffman et al.
Participants were:
Source: Fitzgerald et al.
Source: Hoffman et al.
Source: Hoffman et al.
Source: Hoffman et al.
Three matrices:
Variables:
ID | participants identifierTreatment | placebo, 5.90%, 13.40%Group | Occasional user, Frequent userTimepoint | indicator of which point in the timeline participant’s collection occurredtime.from.start | number of minutes from consumptionYou’ll have access once your groups/repos are created…(today I want people to follow along; there will be time to try on your own soon!)
Where We’re Headed…
Results from: Hubbard et al (2021) Biomarkers of Recent Cannabis Use in Blood, Oral Fluid and Breath link
…and if there’s time PPV and Accuracy post 3h
Source: Fiztgerald et al.